The film is directed by Shirish Kunder and produced by his wife Farah Khan.
"So thrilled that Jacqueline makes her digital debut with our film Mrs Serial Killer. Shirish and I are excited and also gearing up to give the audience something completely new and unexpected," Farah said in a statement.
Jacqueline took to Twitter to express her excitement as well. "Super stoked to announce my new Netflix original Mrs. Serial Killer is coming soon. This is going to be fun," she tweeted.
Mrs Serial Killer is slated to be released on the streaming platform later this year.
By the end of 2020, 15 new original Indian films - including previously announced titles Music Teacher, Cobalt Blue, Chopsticks, Upstarts and Bulbul - will be available to Netflix subscribers around the world.
Images: Jacqueline on Instagram